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KMID : 0942820110100010008
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Journal of Korean Brain Tumor Society
2011 Volume.10 No. 1 p.8 ~ p.14
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BCNU and Temozolomide Chemotherapy in Primary Glioblastoma Multiforme Patients
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Yun Dong-Ju
Kim Hyung-Dong
Kim Ki-Uk
Song Young-Jin
Ahn Sang-Soak
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Abstract
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Background: Since 2005, temozolomide (TMZ) has replaced BCNU as a standard initial chemotherapeutic agent for glioblastoma multiforme (GBM) treatment. Few articles, however, have compared BCNU and TMZ as concomitant and/or adjuvant chemotherapeutic agents. We studied a retrospective analysis comparing BCNU plus radiotherapy (RT) with TMZ plus RT on patients who were diagnosed with primary GBM in the past 14 years at the our hospital.
Patients and Methods: Seventy-four patients (≥14 years) who had been treated for histologically confirmed GBM between January 1995 and December 2008 at our hospital were included in this study. Of the 74 patients, 20 patients who had received BCNU plus RT, and 34 patients who had received TMZ plus RT, were included in this study. Overall survival (OS) and progression free survival (PFS) versus the type of chemotherapy was analyzed.
Result:On univariate analysis, median OS in the BCNU group and TMZ group were 10 and 16 months respectively. However, the curves were significantly different (p=0.044). On multivariate analysis, it was not significant (HR=1.121, 95% CI, 0.513-2.451 ; p=0.775). The median PFS was 8 months equally and the curves were not significantly different (p=0.461) on univariate analysis. It was also not significant on multivariate analysis (HR=0.716, 95% CI, 0.341-1.501 ; p=0.376).
Conclusion: The effectiveness of the BCNU and TMZ did not have a statistically significant difference in terms of the patients’ survival rate and tumor progression. Because TMZ is less toxic than BCNU and the modalities of administration of TMZ are more easeful than those of BCNU, TMZ could be the more preferred chemotherapy agent.
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KEYWORD
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BCNU, Temozolomide, Chemotherapy, Glioblastoma multiforme
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